The University of Tokyo · Graduate School of Medical Sciences / Faculty of Medicine · 講師

Research keywordsParkinson disease・LRRK2・Rab GTPases・alpha-synuclein・autophagy・lysosomal stress・Caenorhabditis elegans・dopamine neurons・mitochondrial dysfunction・endocytic pathway

This is a public-data preview. Personalized fit, contact angles, and saved workflows require sign-in.

• Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans.
• Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress
• Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955
• CASM mediates LRRK2 recruitment and activation under lysosomal stress

• リソソーム過積載ストレス制御法の開発と疾患修飾への応用
• LRRK2によるリソソーム恒常性維持機構およびパーキンソン病との関連
• 神経変性疾患におけるストレス依存的な凝集タンパク質の生成・放出機構
• アルツハイマー血液バイオマーカー：経頭蓋リンパ系放出機構と病態生理学的意義の確立

• Official profile