The University of Tokyo · Graduate School of Frontier Sciences · 教授

Research keywordstRNA biology・genetic code・RNA processing・mitochondrial tRNA・wobble modification・translation fidelity・tRNA maturation・ribonucleases

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• Mechanistic insights into m6A modification of U6 snRNA by human METTL16.
• Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance.
• Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression.
• Structures and functions of Qβ replicase: translation factors beyond protein synthesis.

• ノンコーディングRNAネオタクソノミ
• 高次生命現象を制御する鋳型非依存的RNA合成酵素の構造と機能
• ncRNA作動エレメントの配列構造の同定
• 鋳型非依存性RNAポリメラーゼCCA付加酵素によるCCA付加の動画の作製

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