The University of Tokyo · Graduate School of Medical Sciences / Faculty of Medicine · 助教

Research keywordsrenal proximal tubule・NBCe1・bicarbonate transport・kidney transplantation・hemodialysis・acute kidney injury・Dent disease

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• Molecular mechanisms of renal and extrarenal manifestations caused by inactivation of the electrogenic Na(+)-HCO3 (-) cotransporter NBCe1.
• Angiotensin II dose-dependently stimulates human renal proximal tubule transport by the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway.
• Functional characterization of nonsynonymous single nucleotide polymorphisms in the electrogenic Na+-HCO (3) (-) cotransporter NBCe1A
• Therapeutic effect of prenatal alkalization and PTC124 in Na+/ HCO3- cotransporter 1 p.W516*knock-in mice

• 腎臓における糖代謝調節機構とその破綻の分子メカニズム
• 近位尿細管輸送とエンドサイトーシスにおけるV-ATPase/mTORCの意義
• 近位尿細管におけるAMPK/mTOR経路の意義の解明
• 近位尿細管におけるmTORC2の生理的な意義の解明

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