The University of Tokyo · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 助教

Research keywordsdrug transporter phenotyping・OATP1B Biomarkers・cholestatic liver disease・proteome profiling・orthogonal linear separation analysis・ubiquitination of hepatic transporters・4-phenylbutyrate Pharmacokinetics・blood-brain barrier transporters・single-molecule enzyme assays・extracellular vesicle barcoding

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• Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators
• Investigation of the usefulness of liver-specific deconvolution method toward legacy data utilization
• Establishment of a longitudinally tractable mouse model of cholestatic liver injury via drinking water administration of MDA
• Investigation of chemical structure recognition by encoder-decoder models in learning progress.

• 新規プロファイルデータ解析手法を用いたリード化合物最適化法の構築
• 新規抗動脈硬化症薬開発を指向した脂質輸送担体の分解を司るユビキチンリガーゼの探索
• 未踏化合物群の探索に向けた深層学習モデル開発
• 薬剤誘導性消化器毒性の包括的理解のための新規評価系の構築および定量的リスク予測

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