The University of Tokyo · Institute for Quantitative Biosciences · 特任講師

Research keywordsstructural biology・Na K ATPase・cardiotonic steroids・cryo-EM・cohesin・condensin・protein crystallography・lipid scramblase

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• Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: Substrate binding and arrangement of the catalytic site
• The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase.
• Effects of essential carbohydrate/aromatic stacking interaction with Tyr100 and Phe259 on substrate binding of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp 1011
• ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding

• パリトキシンによるナトリウムポンプのチャネル化機構の構造生物学
• P型ATPaseによる能動輸送機構の構造的解明
• イオンポンプ蛋白質作動機構の構造的理解の完成とその高次機能の構造生物学への発展
• Na+ポンプによるNa+の選択機構の構造生物学的研究

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