The University of Tokyo · Graduate School of Science / Faculty of Science · 助教

Research keywordsCRISPR-Cas9・prime editing・cryo-EM・guide RNA processing・TnpB enzymes・genome editing

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• Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation2026
• General and robust sample preparation strategies for cryo-EM studies of CRISPR-Cas9 and Cas12 enzymes2025
• Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ22025
• Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?2024

• 異なるクラスに属するCRISPR間における機能的クロストークの解明2025
• 異なるクラスに属するCRISPR間における機能的クロストークの解明2025
• 古細菌における接合を介した遺伝子の水平伝搬の分子機構の解明2024

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