The University of Tokyo · Graduate School of Engineering / Faculty of Engineering · 助教

Research keywordsliver progenitor cells・hepatocyte expansion・biliary tissue engineering・extracellular vesicles・cell reprogramming・tumor spheroids

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• Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes
• Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier
• In vivo CRISPR screening reveals epigenetic regulators of hepatobiliary plasticity.
• Long-term maintenance of functional primary human hepatocytes using small molecules.

• 細胞老化予防への倍数性制御からのアプローチ
• 成人肝細胞のin vitro増殖メカニズムの解明
• 原発性硬化性胆管炎に対する抗線維化治療薬の開発
• 肝星細胞を標的とするカスタムAAVの創出

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