The University of Tokyo · Graduate School of Medical Sciences / Faculty of Medicine · 講師

Research keywordsRNA生物学・免疫

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• The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3’-UTR and promoting Rag1 mRNA expression
• Epstein-Barr virus-encoded Bcl-2 homologue functions as a survival factor in Wp-restricted Burkitt lymphoma cell line P3HR-1.
• The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression
• Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice.

• T細胞の分化・機能と恒常性維持におけるエピトランスクリプトミクス制御の生理的役割の解明
• T細胞特異的CNOT3欠損マウスにおけるT細胞分化・機能異常と自己免疫疾患発症
• mRNAワクチン誘導免疫応答における翻訳制御機構の包括的解析と副反応効果バランス最適化への応用
• 自然免疫系CD8+T細胞による肥満における炎症制御のメカニズム

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