The University of Tokyo · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 特任助教

Research keywords消化管吸収,・薬物性消化管障害,・分子標的治療薬,・小腸オルガノイド,

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• Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys.
• Development of the serotonin release assay with enterochromaffin cell-rich human intestinal organoids for the risk evaluation of drug-induced emesis.
• Quantitative prediction of pharmacokinetic properties of drugs in humans: Recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood-brain barrier.
• Investigation of differentiation conditions for canine duodenum, upper jejunum, and ileum crypt-derived cells for drug transport and metabolism.

• 動物/ヒト消化管幹細胞培養系を用いた薬剤誘導性消化器毒性評価系の構築
• ヒト小腸オルガノイドを用いた薬剤誘導性悪心・嘔吐リスクの動物実験代替予測法の確立
• 薬物曝露によるセロトニン放出機序の理解と新規制吐薬開発に向けた基礎検討

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