The University of Tokyo · Institute for Quantitative Biosciences

Research keywordsシトクロムP450・PCB代謝・エナンチオ選択的水酸化・環境汚染物質・薬物代謝酵素

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• Enantioselective metabolism of chiral polychlorinated biphenyl 2,2',3,4,4',5',6-Heptachlorobiphenyl (CB183) by human and rat CYP2B subfamilies.
• Hydroxylation and dechlorination of 3,3',4,4'-tetrachlorobiphenyl (CB77) by rat and human CYP1A1s and critical roles of amino acids composing their substrate-binding cavity.
• A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings.
• From the Cover: Structural Determinants of the Position of 2,3',4,4',5-Pentachlorobiphenyl (CB118) Hydroxylation by Mammalian Cytochrome P450 Monooxygenases.

• 細胞外小胞を介した脳―精巣上体相関による、ストレスの次世代継承メカニズムの解明
• Long non-coding RNAから翻訳される新規ポリペプチドの機能解析
• 加齢に伴う精子エピゲノム変化が次世代に継承される分子基盤の解明

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