The University of Tokyo · Institute for Quantitative Biosciences · 准教授

Research keywordsnucleosome stability・histone variants・chromatin structure・H4K20 monomethylation・cryo-EM of nucleosomes・heterochromatin spreading・DNA lesion-containing nucleosomes・glucose-6-phosphate dehydrogenase deficiency・acute myeloid leukemia peptides

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• Crystal structure of the overlapping dinucleosome composed of hexasome and octasome.
• Incorporation and influence of Leishmania histone H3 in chromatin.
• Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome
• Structure and function of human histone H3.Y nucleosome.

• (IUCr) Act...
• 細胞核膜近傍におけるクロマチンの機能・構造解明
• (IUCr) Acta Crystallographica Section D 査読
• 溶血性貧血の原因となる代謝疾患G6PD欠乏症における酵素活性化と活性化機構の解明

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