The University of Tokyo · Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences · 助教

Research keywords分裂期作用薬・分裂期紡錘体・中心体・微小管・ガンマチューブリン特異的阻害薬

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• Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay.
• Multimodal mechanisms of human centriole engagement and disengagement.
• Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.
• Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria.

• 微小管-紡錘体極マトリクスからなるLLPS複合体形成を介した、タキソールの抗がんメカニズムの解明
• 分裂期を標的とする相分離誘導薬の創製
• 遺伝学的解析可能な多剤超感受性酵母の作製と薬剤標的分子・作用機構解析への応用
• 染色体数に応じた紡錘体形状の適応メカニズムの解明

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