The University of Tokyo · Graduate School of Engineering / Faculty of Engineering · 教授

Research keywordsnucleic acid delivery・mRNA delivery・polyplexes・antisense oligonucleotides・polymer therapeutics・nanomedicine

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• Formulation-Driven Control of mRNA Polyplex Physicochemical Properties Enables Spleen-Targeted Systemic Delivery.2026
• Structurally Dynamic Polyplexes Enhance Sentinel Lymph Node Delivery of Antisense Oligonucleotides to Inhibit Breast Cancer Recurrence and Metastasis.2025
• Enhanced Accumulation of Heteroduplex Oligonucleotides in Dystrophin-Deficient Skeletal Muscles by Single Oligonucleotide-Loaded Unit Polyion Complexes.2025
• Silica-coated polyion complexes for enhanced pulmonary messenger RNA delivery with optimized silica layer stability.2025

• 自発分解性ポリペプチドの精密分子設計と免疫原性回避への挑戦2024
• ユニットPICを起点とする次世代核酸ナノ医薬の創製と生体内バリア突破に向けた挑戦2024
• 凝集誘起発光性ナノ構造体の構築と関節リュウマチのホリスティック療法への挑戦2023
• 単鎖抗体mRNAネブライジングによる多剤耐性菌治療法の開拓2023

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