The University of Tokyo · Graduate School of Agricultural and Life Sciences / Faculty of Agriculture

Research keywords胚発生・発生生物学・幹細胞生物学・キメラ

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• Generation of Blastoids from Human Naïve Pluripotent Stem Cells
• Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee.
• Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate.
• OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.

• 遺伝子改変マウスを用いた成熟肝細胞への新規ｉｎ ｖｉｔｒｏ分化誘導系の構築
• ヒト幹細胞を用いた着床期胚発生機構の構成的理解
• ヒトナイーブ型ES/iPS細胞を用いた、三次元ヒト初期胚発生モデルの構築
• 移植用ヒト固形臓器作出を目的とした協調的ヒト→動物キメラ作出技術の開発

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