The University of Tokyo · Graduate School of Arts and Sciences・College of Arts and Sciences · 教授

Research keywordsinsulin secretion・neuroendocrine exocytosis・live-cell biosensors・fluorescent protein indicators・FRET imaging・pancreatic beta cells・enteroendocrine cells・astrocyte signaling

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• Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing
• Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes.
• Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells
• Integrative function of adrenaline receptors for glucagon-like peptide-1 exocytosis in enteroendocrine L cell line GLUTag

• 長期ストレス暴露を証明する法医分子病理学的診断法の開発-下垂体を標的として-
• 開口放出様式を制御する分子機構の可視化解析
• 腸内細菌代謝物による消化管ホルモン分泌制御機構の解明
• グルコース非依存的エネルギー産生機構による細胞生理機能の解明

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