The University of Tokyo · Graduate School of Frontier Sciences · 教授

Research keywords白血病・転写因子・エピジェネティクス・造血系腫瘍・腫瘍免疫

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• MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2
• Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.
• IMPDH阻害剤による新規白血病治療法の開発
• Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

• タンパク質間相互作用制御に基づく転写・エピゲノム因子標的療法の開発
• MDS、再生不良性貧血、PNH、LGLLの関係性とクローン性造血の関与
• 難治性白血病マウスモデルの構築と新規治療法の開発
• 白血病原因遺伝子Evi-1の統合的機能解析

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