The University of Tokyo · Research Center for Advanced Science and Technology · 教授

Research fieldsStructural biochemistry

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• Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
• Application of Intramolecular O-to-N Phosphoryl Transfer Reaction to Design Fluorogenic Probes to Detect Activities of Enzymes That Metabolize Short Peptides and Acylamino Acids.
• Rapid protein evolution by few-shot learning with a protein language model.
• [Structural biology of ubiquitin signaling].

• RNA依存性エフェクター複合体の構造機能解析
• 自然免疫に関与する多様なRNAヘリカーゼの構造機能解析
• デジタル検出技術を基盤としたウイルスの新規感染診断法の開発
• 小分子RNAを含むリボヌクレオプロテイン複合体の機能の構造基盤の解明

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