The University of Tokyo · Institute for Quantitative Biosciences · 助教

Research keywordsPD-1 signaling・LAG-3・T cell inhibition・autoimmunity・dendritic cell immunoreceptor・arthritis models・osteo-immunology・C-type lectin receptors・osteoclastogenesis・immune checkpoint biology

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• The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17.
• PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation.
• DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling.
• PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.

• ペプチド－MHCII複合体の構造多様性の生物学的意義の解明
• 骨免疫疾患における樹状細胞受容体Dcirの機能解明
• LAG-3の抑制機能作動原理および制御機構の解明
• LAG-3によるself-pMHCII認識を起点とした恒常性維持機構の解明

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