The University of Tokyo · Graduate School of Science / Faculty of Science · 教授

Research keywordsRNAサイレンシング・piRNA・遺伝子発現制御・RNA結合タンパク質・核内輸送

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• Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons
• Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.
• Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.
• Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.

• ノンコーディングRNAネオタクソノミの実現を加速する国際活動支援
• 内在性遺伝子発現制御に関わるRNAi関連分子の機能解析
• RNA結合蛋白質の発現異常に伴うヒト遺伝病の分子機能解析
• 機動性DNAエレメントと宿主がおりなす生物多様性創出：宿主対応と継世代伝播

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