The University of Tokyo · Institute for Quantitative Biosciences · 准教授

Research keywordssingle-cell transcriptomics・epigenetics・microglia・neocortex development・chromatin accessibility・neural progenitors・brain aging

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• IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells
• Isolation of genetically manipulated neural progenitors and immature neurons from embryonic mouse neocortex by FACS.
• In utero gene transfer system for embryos before neural tube closure reveals a role for Hmga2 in the onset of neurogenesis
• Plag1 regulates neuronal gene expression and neuronal differentiation of neocortical neural progenitor cells.

• クロマチン制御を介した神経幹細胞の運命転換メカニズムの解明
• エピゲノム操作を介したニューロン若返りによる脳卒中後のリハビリ促進法の開発
• FISHを用いた異なる機能のニューロンの新規分取法の開発による包括的エピゲノム解析
• 生体内ニューロン分化過程におけるクロマチンポテンシャルの解析

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