The University of Tokyo · Institute for Quantitative Biosciences

Research keywordspiRNA clusters・Rhino protein・ADMA histones・transposon silencing・ZAD zinc finger proteins・Drosophila genomics・anti-silencing systems・Arabidopsis evolution

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• Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins inDrosophila
• ADMA-histones play a crucial role in the initial recognition of dual-strand piRNA cluster regions by Rhino
• ADMA-histones define genomic loading of Rhino at the initial step of piRNA cluster formation
• Role of ADMA-histones in dual-strand piRNA source loci recognition by Rhino

• トランスポゾンに局在する多細胞生物SMC複合体の生物学的意義
• piRNA clusterを定義する因子Rhinoと共局在する新規ヒストン修飾の機能と制御
• トランスポゾンの抗抑制因子が備える配列特異性創出機構の解明・応用
• piRNA clusterの転写を担う因子Rhinoの標的認識機構

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