The University of Tokyo · Graduate School of Medical Sciences / Faculty of Medicine · 特任准教授

Research keywords神経過活動・神経変性疾患・くも膜・グリアリンパ系・タウ・タウオパチー・硬膜リンパ管・光遺伝学

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• Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.
• The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
• Multifaceted Roles of Aquaporins in the Pathogenesis of Alzheimer’s Disease
• Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver.

• アルツハイマー病Aβの脳内エコノミー破綻によるタウ依存的神経障害の分子基盤解明
• 細胞間伝播を導くタウの細胞外放出の分子機構の解明
• 細胞間伝播を導くタウの細胞外量調節機構の解明
• αシヌクレインの細胞外放出と細胞間伝播に関する研究

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