The University of Tokyo · Graduate School of Engineering / Faculty of Engineering · 助教

Research keywordsアプタマーセンサー・量子トンネル電流計測・DNAシーケンシング・核酸修飾検出・ユビキチン鎖・標的タンパク質分解

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• Highly Conductive Nucleotide Analogue Facilitates Base-Calling in Quantum-Tunneling-Based DNA Sequencing.
• Chemical-Labeling-Assisted Detection of Nucleobase Modifications by Quantum-Tunneling-Based Single-Molecule Sensing.
• Chemical Diversification of Enzymatically Assembled Polyubiquitin Chains to Decipher the Ubiquitin Codes Programmed on the Branch Structure
• Indirect ubiquitination independent of endogenous ubiquitination machinery for targeted protein degradation

• 主鎖で連結した直列型ユビキチン鎖の非酵素的修飾を介したタンパク質標的分解
• １分子解析技術による網羅的頻度解析が可能な人工核酸分子タグの創製
• 超効率な標的タンパク質分解を実現する分解特化型精密分岐ユビキチン鎖の創出
• 不均一ポリユビキチン鎖とシャトル因子の”ライブラリ×ライブラリ”相互作用解析

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