The University of Tokyo · Graduate School of Science / Faculty of Science · 教授

Research keywords生物学・基礎生命科学・紡錘体形成・受精卵形成・Spindle formation・細胞分裂・Meiotic/Mitotic chromosome dynamics

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• Abnormal mitosis and genetic instability induced by downregulation of candidate myeloid tumor suppressor genes isolated from the long arm of chromosome 7.
• Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes (vol 146, pg 568, 2011)
• Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin
• The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

• 受精卵への雌性ゲノム継承を保証する哺乳類特有の制御機構
• クロモキネシンKidによる分裂後期の染色体動態と娘細胞核形成の制御機構
• DNA結合能を有するキネシン様モーターKidの染色体分配における機能と制御機構
• マウス卵割期胚におけるNC比制御と核形態・クロマチン状態変化の解析

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