Niigata　University　of　Pharmacy　and　Applied　Life　Sciences · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 教授

Research keywordsMDA5・RIG-I様受容体・自然免疫・ウイルス感染防御・tRNAリサイクリング

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• PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2
• Transcription from the proximal promoter of ELAC1, a gene for tRNA repair, is upregulated by interferons
• C. S. Friedman, M. O'Donnell, D. Legarda-Addison, A. Ng, W. B. Cardenas, J. S. Yount, T. M. Moran, C. F. Basler, A. Komuro, C. M. Horvath, R. Xavier, A. T. Ting.Tumor suppressor CYLD is a negative regulator of RIG-I-mediated anti-viral response
• Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H.Mutant Huntingtin impairs Ku70-mediated DNA repair

• 2023/04～2025/03 ウイルス感染防御におけるtRNAリサイクリングの生理的役割 競争的資金等の外部資金による研究2023 · 研究課題・受託研究・科研費
• 発達障害・変性疾患のシナプスダイナミックパソロジーの解明
• ウイルス感染防御におけるtRNAリサイクリングの生理的役割

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