Gifu　University　of　Medical　Science · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 准教授

Research keywords動脈硬化症・スフィンゴシン１-リン酸・PAI-1・microRNA

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• Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1.
• Increased expression of plasminogen activator inhibitor type-1 (PAI-1) in HEPG2 cells induced by insulin mediated by the 3 '-untranslated region of the PAI-1 gene and its pharmacologic implications
• Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP
• Circulating level of microRNA-126 may be a potential biomarker for recovery from smoking-related vascular damage in middle-aged habitual smokers

• 新規 S1P 供与体を用いた初期動脈硬化病変の先駆的治療法の開発
• 動脈硬化発症の初期病変を効率的に評価可能なバイオマーカーの探索
• スフィンゴシン誘導体による脂質輸送および脂質産生量調節を介した新規抗炎症・再灌流傷害抑制機構の解明
• 分泌型miRNAの測定による新規な動脈硬化発症・進展評価法の開発

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