Gifu Pharmaceutical University · 薬学部 · 教授

Research keywords臨床薬剤学・Clinical pharmaceutics・Pathological biochemistry・病態生化学

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• Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients
• Luteolin suppresses the differentiation of THP-1 cells through the inhibition of NOX2 mRNA expression and the membrane translocation of p47 phox
• Association of extracellular-superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase polymorphism
• Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2α/ATF4 axis in HAPI cells

• 活性酸素の産生酵素および消去酵素の挙動と病態との関連の解明
• 活性酸素消去機構の恒常性の破綻に起因する病態の発症とその分子機構
• 細胞内グルタチオンによる異物代謝排泄と活性酸素調節剤を利用したその制御
• 網膜血管系のレドクス恒常性維持機構の破綻に起因する病態増悪メカニズムの解明

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