Gifu Pharmaceutical University · Center for Promotion of Green Pharmacy Education · 教授

Research keywordsアルドケト還元酵素・ステロイド代謝・酸化リポタンパク・活性酸素種・薬学

Research fieldsPathological medical chemistry・Tumor biology・薬系衛生、生物化学

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• Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-γ-dependent mechanism.
• Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators.
• Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells.
• Localization of oxidized HDL in atheromatous plaques and oxidized HDL binding sites on human aortic endothelial cells

• 糖化高密度リポタンパクは血管内皮細胞を動脈硬化へと導くか？
• 癌マーカーのアルド-ケト還元酵素を標的とする制癌剤の開発
• アルドケト還元酵素を標的とするホルモン依存性がんアジュバント療法剤の開発
• 高反応性脂質アルデヒド代謝酵素を標的とした肺がんアジュバント療法剤の開発

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