Kyushu　University　of　Health　And　Welfare · Department of Pharmacy

Research keywordsAGEs・内皮機能障害・慢性炎症・生活習慣病血管障害・糖尿病・細胞外核酸・研究テーマ: ・生活習慣病時における血管機能障害分子機序の解明 ・様々な物質の血管機能への直接的影響とその機序の解明・腸内細菌代謝物・血管内皮由来収縮因子・血管内皮由来過分極因子

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• Mechanisms Underlying Enhanced Noradrenaline-Induced Femoral Arterial Contractions of Spontaneously Hypertensive Rats: Involvement of Endothelium-Derived Factors and Cyclooxygenase-Derived Prostanoids
• Relationships among protein tyrosine phosphatase 1B, angiotensin II, and insulin-mediated aortic responses in type 2 diabetic Goto-Kakizaki rats
• Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ET(A) receptors and ERK
• Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia

• 糖尿病性血管合併症の研究
• 糖尿病性細小血管障害におけるアディポサイトカインの関与
• 糖尿病性血管障害におけるウリジンアデノシンテトラフォスフェートの生理的意義
• 糖尿病性細小血管障害における内皮由来過分極因子シグナルに対するAGEの影響

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