The University of Shiga Prefecture · Faculty of Human Culture, Department of Food and Nutrition

Research keywordsヘスペレチン・クルクミン・カプサイシン・癌幹細胞・アポトーシス・上皮間葉転換

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• Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax2022 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 参加形態： 共同（副担当） DOI： 10.3892/ijo.2022.5433
• Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad2020 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Bioscience, Biotechnology and Biochemistry 参加形態： 共同（主担当） The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade. DOI： 10.1080/09168451.2020.1808443 Scopus その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089869160&origin=inward
• C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice.2017 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 参加形態： 共同（副担当）
• Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.2014 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 参加形態： 共同（主担当）

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