The University of Shiga Prefecture · Unclassified

Research keywordsHsp70-mediated apoptosis・lung cancer cells・influenza A pathogenesis・vascular endothelial permeability・GSK-3beta and beta-catenin signaling・Toll-like receptor signaling・secretory IgA responses・surfactant protein C・cardiomyocyte infection・14-3-3 proteins

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• Hesperetin induces apoptosis in A549 cells via the Hsp70-mediated activation of Bax2022 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 参加形態： 共同（主担当） DOI： 10.3892/ijo.2022.5433
• Curcumin induces apoptosis in lung cancer cells by 14-3-3 protein-mediated activation of Bad2020 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 出版者・発行元： Bioscience, Biotechnology and Biochemistry The anticancer effects of curcumin are based on the induction of apoptosis, but the specific mechanisms have not yet been fully elucidated. To address this issue, we investigated the effects of curcumin on the intrinsic apoptosis pathway using mitochondria from A549 cells. Curcumin decreased the levels of 14-3-3 proteins, key molecules that inhibit the activation of proapoptotic factors known as BH3-only proteins (e.g. Bad). Curcumin-induced suppression of 14-3-3 protein levels was associated with reduced cytosolic Bad and elevation of mitochondrial Bad, leading to a drop in the mitochondrial membrane potential. 14-3-3 proteins generally interact with Bad phosphorylated by AKT, thus preventing its translocation to the mitochondria where it can promote cell death. Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion. Our results provide novel evidence for the induction of apoptosis by curcumin at multiple stages of the mitochondrial cascade. DOI： 10.1080/09168451.2020.1808443 Scopus その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85089869160&origin=inward
• Visual 栄養学テキスト 人体の構造と機能および疾病の成り立ちⅢ 疾病の成り立ち2017 · 中山書店 2017年9月 （ ISBN: 978-4-521-74286-1 ）
• Relationship between dietary patterns and brachial-ankle pulse wave velocity among middle-aged aduluts in Japan2016 · 記述言語： 英語 掲載種別： 研究論文（学術雑誌） 参加形態： 共同（副担当） DOI： 10.6133/apjcn.032016.14

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