Keio University · Faculty of Science and Engineering / Graduate School of Science and Engineering · 教授

Research keywordsmicrobial natural products・thermotolerant Streptomyces・antiviral metabolites・tau degradation・molecular glue discovery・Notch-targeted drug discovery

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• Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata2022 · ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
• Erratum: Two Bioactive Compounds, Uniformides A and B, Isolated from a Culture of Nocardia uniformis IFM0856Tin the Presence of Animal Cells (Organic Letters (2022) 24:27 (4998-5002) DOI: 10.1021/acs.orglett.2c02092)2022 · Organic Letters
• 病原微生物の浸潤進化に学ぶ休眠遺伝子活性化と創薬2022 · 上原記念生命科学財団研究報告集
• Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses2022 · Journal of Natural Products

• タンパク質ビーズ法による人工天然物エキスからの新規タウ分解分子のりの開発2023 · -
• 化合物潜在空間の深化に資する包括的活性評価と微生物由来天然物の拡充2023 · -
• 病原微生物の「浸潤進化」に学ぶ休眠遺伝子活性化と創薬シード分子の創製2021 · -
• がん不均一性の克服に寄与する高活性天然物の探索と機能解明2020 · -