The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine · 教授

Research keywordsDNA damage signaling・p53 apoptosis・DYRK2 regulation・breast cancer metastasis・checkpoint kinases・tumor cell signaling

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• Serum PKCδ is a useful biomarker to distinguish hepatocellular carcinoma from other gastrointestinal cancers
• Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis.
• Primary cilia are required for cell-type determination and angiogenesis in the pituitary development.
• DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage.

• DYRKファミリーによる肝がん免疫微小環境改変と将来的な治療応用への検証研究
• 大腸癌遠隔転移におけるPKCδの機能解析

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