Tokyo University of Pharmacy and Life Sciences · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 其他

Research keywordsSLC46A3 transporter・trastuzumab emtansine・drug-ADC interaction・flavonoid inhibitors・lysosomal transport・HER2-positive breast cancer

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• Exploring flavonoids as potent SLC46A3 inhibitors: Insights from the structural characteristics of flavonoid-SLC46A3 interactions.2025 · Biochemical pharmacology
• Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy.2023 · Molecular pharmaceutics
• SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1.2022 · PNAS nexus