Yamaguchi University · Graduate School of Medical Sciences

Research keywordsHSF1 transcriptional complexes・heat shock response・phase-separated condensates・MED12・TRRAP-TIP60 complex・proteotoxic stress・chromatin remodeling・mitochondrial protection

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• HSF1/HSP25 system protects mitochondria function from heat stress and assists steroidogenesis in MA-10 Leydig cells2025 · Molecular and Cellular Endocrinology
• HSF1 is required for cellular adaptation to daily temperature fluctuations2024 · Scientific Reports
• Regulation of HSF1 transcriptional complexes under proteotoxic stress: Mechanisms of heat shock gene transcription involve the stress-induced HSF1 complex formation, changes in chromatin states, and formation of phase-separated condensates: Mechanisms of heat shock gene transcription involve the stress-induced HSF1 complex formation, changes in chromatin states, and formation of phase-separated condensates.2023 · BioEssays : news and reviews in molecular, cellular and developmental biology
• The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells.2023 · FEBS letters

• 熱ショック転写因子による脂質代謝と細胞増殖に関連するクロマチン制御機構の解明2024 · 科学研究費助成事業
• TurboID法により同定した新規アセチル化酵素群によるHSF1転写制御機構の解明2023 · 科学研究費助成事業
• 温暖化にともなう⽇周温度変動への細胞の適応機構に関する基礎的研究2023 · 環境研究助成
• クロマチン制御による熱ショック応答の調節機構の解明2021 · 科学研究費助成事業

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