Yamaguchi University · Graduate School of Medical Sciences

Research keywordsCAR-T cells・IL-7 and CCL19・solid tumor immunotherapy・glioblastoma・pancreatic cancer・GM2-targeted CAR-T・c-Met CAR-T・tumor-specific TCR T cells・PD-1 blockade・epitope spreading

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• CAR-T cells co-expressing IL-7 and CCL19 promote epitope spreading to enhance antitumor immunity2026 · Cancer Immunol Immunother
• Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer2024 · Cancer Research Communications
• Therapeutic effects of anti‐GM2 CAR‐T cells expressing IL‐7 and CCL19 for GM2‐positive solid cancer in xenograft model2023 · Cancer Medicine
• Enhanced Antitumor Responses of Tumor Antigen-Specific TCR T Cells Genetically Engineered to Produce IL7 and CCL19.2022 · Molecular cancer therapeutics

• 固形がんに対する次世代型CAR-NK細胞療法の研究開発2022 · 科学研究費助成事業
• 固形がんに対する新規CAR-T細胞技術のメカニズム解析研究2021 · 科学研究費助成事業
• 悪性中皮腫に対する次世代型CAR-T細胞療法の開発2019 · 科学研究費助成事業
• 免疫チェックポイント阻害療法のさらなる効果向上を目指した基盤的がん免疫研究2016 · 科学研究費助成事業

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