国際医療福祉大学 · 医学部 · 教授

研究关键词cardiac development・congenital heart disease・Nkx2-5・cardiomyocyte differentiation・sarcomere assembly・calcium handling・myosin light chain kinase・heart failure

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• Crystallization and preliminary X-ray analysis of the NKX2.5 homeodomain in complex with DNA.
• Crystal structure of the human NKX2.5 homeodomain in complex with DNA target.
• Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.
• Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies.

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