International University of Health and Welfare · Faculty of Medicine · 教授

Research keywordscardiac development・congenital heart disease・Nkx2-5・cardiomyocyte differentiation・sarcomere assembly・calcium handling・myosin light chain kinase・heart failure

This is a public-data preview. Personalized fit, contact angles, and saved workflows require sign-in.

• Crystallization and preliminary X-ray analysis of the NKX2.5 homeodomain in complex with DNA.
• Crystal structure of the human NKX2.5 homeodomain in complex with DNA target.
• Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.
• Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies.

• Official profile