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Home›Data center›Researcher database›Hatakeyama shigetsugu

教授

Hatakeyama shigetsugu

畠山 鎮次

Hokkaido University · Faculty of Medicine / Graduate School of Medicine / Medical Research Institute

Affiliation
Hokkaido University · Faculty of Medicine / Graduate School of Medicine / Medical Research Institute
Research keywords
TRIMタンパク質, ユビキチンリガーゼ, Molecular, ligase, タンパク質分解, ユビキチン, プロテアソーム, Ubiquitin
Research fields
General medical chemistry, Experimental pathology, Functional biochemistry, Pathological medical chemistry, Neurology, Immunology, 内科, Clinical internal medicine, Molecular biology, Medicine, Medicine, Dentistry, and Pharmacy, Basic medicine, 基礎生物科学, Clinical surgery, Informatics, Biomedical structure and function and related fields, Bioinformatics/Life informatics, 生物化学, Biology, Biological science
Funded projects
60 grants · latest 2024

Recent work

  • Bacterial extracellular vesicle ssRNA prevents colorectal cancer progression via Piezo1.（2025）
  • PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region.（2025）
  • Development of a Myogenin minimal promoter-based system for visualizing the degree of myogenic differentiation（2024）
  • Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders.（2024）
  • Sez6l2 autoimmunity in a large cohort study.（2023）

Funded projects

  • CD4サイレンシングの分子機構とリンパ球分化過程におけるRunxの役割の解明
  • プロテオーム解析による頭頸部癌診断・治療の新しい展開
  • TRIM型ユビキチンリガーゼの物性と動作原理の解析
  • 性ホルモン受容体のユヒキチン化介在性分解による癌細胞増殖制御機構
  • 抗原認識受容体シグナル関連分子の網羅的解析

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